Can omeprazole make osteoporosis worse? ·

26 Aug 2024, 00:00

In animal studies the PPI omeprazole reduced bone density [68,69]. In contrast, some human studies report no effect of PPIs to cause alterations in bone turnover and/or bone density as well as no effect at causing osteoporosis [67].

Can omeprazole hurt your bones?

The present study corroborates the previous findings, given that a relationship between omeprazole use and decreased bone mineral density was demonstrated. This can be taken to be a predictive sign indicating that fractures may occur as a result of long-term PPI use.

Do proton pump inhibitors make osteoporosis worse?

In September 2012, the US Food and Drug Administration issued a warning regarding use of proton pump inhibitors (PPIs) and osteoporosis stating that “several published observational studies suggest that proton pump inhibitor (PPI) therapy may be associated with an increased risk for osteoporosis-related fractures of ...

Can omeprazole cause osteopenia?

Conclusion: Short-term administration of omeprazole has no significant influence on bone density and does not increase the incidence of osteopenia and osteoporosis.

What medications make osteoporosis worse?

High doses of corticosteroids.
High doses of thyroid medicines.
Medicines that reduce levels of sex hormones.
Certain diabetes medicines.
Certain stomach medicines, such as proton pump inhibitors or antacids containing aluminum.
Certain antidepressants.
Mood stabilizers containing lithium.

How and When to take Omeprazole (Prilosec / Losec) | Side Effects All Patients Need to Know

What are the two medications that may cause osteoporosis after long-term use?

High doses or long-term use of medicines called proton pump inhibitors (PPIs) can raise the risk of bone loss. PPIs, such as esomeprazole, lansoprazole, and omeprazole, are used for GERD (acid reflux), peptic ulcer, or heartburn. However, getting enough calcium and vitamin D may be enough to lower the risk.

What medications decrease bone density?

Many drugs can affect bone metabolism. As an example, heparin, warfarin, cyclosporine, glucocorticoids, medroxyprogesterone acetate, cancer drugs, and thyroid hormone can cause bone loss, while thiazide diuretics can minimize bone loss [1,2]. This topic will review the skeletal effects of some of these drugs.

Is it OK to take omeprazole if you have osteoporosis?

Does omeprazole block calcium absorption?

PPI therapy and Calcium Absorption

Six studies have directly examined the effect of PPI therapy upon calcium absorption (Table 1) [51–56] Four of the studies suggested that omeprazole therapy may impair dietary calcium absorption [51–54].

Can acid reflux cause osteoporosis?

Gastroesophageal reflux disease (GERD) with proton pump inhibitor (PPI) use is associated with an increased risk of osteoporosis.

Can acid reflux affect your bones?

Changing the acidity of your digestive system affects your body's ability to absorb bone-boosting calcium. Long-term use of PPIs may also cause vitamin B-12 deficiency. This damages your nerves and increases your risk for falls.

Do antacids cause osteoporosis?

Indiscriminate use of over-the-counter antacids may be weakening your bones. Acidity and reflux is a bane of our stressful times. Most do not think twice before popping an antacid to check heartburn, but doctors warn that regular consumption of the drug can weaken your bones and cause osteoporosis.

Is there an alternative to omeprazole?

There are three types of medicines that treat symptoms like heartburn. These include proton pump inhibitors such as esomeprazole (Nexium), omeprazole (Prilosec), pantoprazole (Protonix) and lansoprazole (Prevacid).

Does omeprazole affect vitamin D?

No interactions were found between omeprazole and Vitamin D3.

Can I take omeprazole with calcium and vitamin D?

Interactions between your drugs

No interactions were found between calcium / vitamin d and Prilosec.

What supplements should not be taken with omeprazole?

Antacids, including omeprazole, inhibit folic acid absorption. People taking antacids are advised to supplement with folic acid.

Do antacids affect bone density?

May 25, 2010 -- Popular PPI antacids -- Aciphex, Dexilant, Nexium, Prevacid, Prilosec, Protonix, Vimovo, and Zegerid -- raise the risk of bone fracture, especially when used for a year or more or at high doses, the FDA warns.

What is the safest osteoporosis drug 2020?

The U.S. Food and Drug Administration today approved Evenity (romosozumab-aqqg) to treat osteoporosis in postmenopausal women at high risk of breaking a bone (fracture).

What is the best and safest treatment for osteoporosis 2020?

Bisphosphonates are usually the first choice for osteoporosis treatment. These include: Alendronate (Fosamax), a weekly pill. Risedronate (Actonel), a weekly or monthly pill.

Is walking good for osteoporosis?

You can prevent bone loss with regular exercise, such as walking. If you have osteoporosis or fragile bones, regular brisk walking can help to keep your bones strong and reduce the risk of a fracture in the future. How should you walk and how often? You should walk briskly on a regular basis.

What is the most commonly prescribed drug for osteoporosis?

Bisphosphonates: Most Commonly Prescribed For Osteoporosis

Alendronate (Fosamax, Binosto): may be taken orally daily or a weekly tablet is also available.
Ibandronate (Boniva): can be taken orally monthly or given by intravenous injection every three months.

What does osteoporosis pain feel like?

Sudden, severe back pain that gets worse when you are standing or walking with some relief when you lie down. Trouble twisting or bending your body, and pain when you do. Loss of height.

What is considered severe osteoporosis?

Severe (established) osteoporosis is defined as having a bone density that is more than 2.5 SD below the young adult mean with one or more past fractures due to osteoporosis.

What are the dangers of taking omeprazole?

Common Prilosec side effects include headache, stomach pain and nausea. Long-term Prilosec use has been linked to kidney damage, bone fractures and other dangerous side effects.
...
Common side effects of Prilosec (omeprazole) may include:

Headache.
Nausea.
Vomiting.
Dizziness.
Stomach pain.
Constipation.
Diarrhea.
Gas.

Is Gaviscon safer than omeprazole?

There was no significant difference between groups in clinically relevant reduction in pain intensity, although overall qualitative pain relief was slightly (p = 0.049) in favour of omeprazole. Results of the GOOD trial also showed that Gaviscon® and omeprazole 20 mg could be used both safely.

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Can omeprazole make osteoporosis worse?

[embedded content] Six studies have directly examined the effect of PPI therapy upon calcium absorption (Table 1) [5156] Four of the studies suggested that omeprazole therapy may impair dietary calcium absorption [5154].